Research
Keteniminium salts are the cationic intermediates having higly electrophlilic, regioselective and and reactive nature. The keteniminium intermediates are highly functional for organic synthesis leading to formation of biologically activated compounds. These reactive intermediates are used in a broad range of reactions such as 6p/10p electrocyclization, inter/intramolecular [2+2] cycloaddition, Michael addition, Diels Alder and Pictet-Spengler reactions. By means of density functional theory (DFT) the reaction mechanisms are modeled and properties of keteniminium cations are investigated... Read More
Methionine is one of the sulfur-containing amino acids found in proteins which is considered the most hydrophobic specie among the amino acids. Methionine is responsible for the protein synthesis, methylation of DNA and polyamine synthesis in human body. Deprivations of methionine can be used to reduce methionine both in plasma and tumor. Many investigators have attempted to exploit the methionine dependence of tumors for therapeutic effects in vivo. Since methionine free-diet is inefficient due to practical considerations, enzymatic degradation of methionine can be used as an... Read More
